P-193 Comparison of ICSI outcomes and euploidy rates between AI and non-AI sperm selection

Abstract Study question Can artificial intelligence (AI) assisted sperm selection improve intracytoplasmic injection (ICSI) outcomes and euploidy rates? Summary answer AI selected spermatozoa showed no statistical significance in various measures of ICSI but an increasing trend rate can be observed. What is known already All practitioners would like to have objective tool for the injected as it one factors producing successful ICSI. Sperm assistant (SiD: (IVF 2.0 Limited, UK) a real-time identifier that assesses all visual field based on their motility patterns individually. Mendizabal-Ruiz et. al. (2022) reported promising data showing SiD may reduce subjectivity selection, which potentially alternative method our current practice. design, size, duration From June 2022 December 2022, 89 cycles (mean age: 35.3; age range: 26.0–47.0) were done Alpha IVF & Women’s Specialists. A sibling (Group A) non-AI B) study with was performed oocytes retrieved from these cycles. Of which, 76 planned Preimplantation Genetic Testing Aneuploidies (PGT-A) utilizable blastocysts. Participants/materials, setting, methods matured using Piezo-ICSI (Prime Tech Ltd, Japan). Half each cycle whereas other half by manual selection. cultured up day-7 trophectoderm biopsy PGT-A screening (IonTorrent, USA) blastocysts prior vitrification (Cryotec, The fertilization, blastulation, utilization rates assessed both groups. Main results role chance In Group A, fertilization (2PN), abnormal ( > 2PN), blastulation 2PN, blastocyst 2PN 81.5% (419/514), 2.1% (11/514) 77.1 (323/419), 57.5% (241/419) 45.2% (71/157) respectively. B, 79.7% (427/536), 2.8% (15/536), 75.9% (324/427), 59.0% (252/427) 35.5% (60/169) No significant differences observed (p = 0.4828), 0.5545), 0.6861), 0.7278) 0.0898). Although are comparable between two groups, rates. considered assist embryologist selecting better during procedures. Limitations, reasons caution patient sample size small further studies larger certainly seem justified, particularly association PGTA value shall greatly enhanced when spermatozoon morphology also measured. Wider implications findings This more evidence suggesting compared embryologist. addition, could used train embryologists learning Trial registration number not applicable